An 11 year old female came to our institution with complaints of intermittent pain in her left knee in the last two years. The physical examination and laboratory tests were unremarkable.
An 11 year-old female, with complaints of intermittent pain in her left knee in the last two years was referred to our institution. The physical examination and laboratory tests were unremarkable.
The initial radiograph was performed when the complaints of knee pain first started. The frontal radiograph depicts a subtle ovoid, osteolytic lesion involving the metaphysis, the physis, and the epiphysis of the medial proximal left tibia (Figures 1a-1b). The lesion increased in size over a period of nineteen months (Figure 1c-1d), it acquired sclerotic borders, a narrow zone of transition, and at least two smaller internal lytic areas became apparent.
MRI of the left knee was them performed (see Figure 2). In correspondence with the lesion described, a medullary cavity is shown in the metaphysis, the physis, and the epiphysis of the proximal left tibia. The medullary cavity content has low signal in T1-weighted images (WI), has high signal in T2-WI fat suppressed, and enhances after gadolinium contrast, which is consistent with a infectious/inflammatory nature. It communicates with the cortical surface through sinus tracts and contains a small hypointense area on all sequences suggestive of sequestrum. The nearby bone marrow exhibits low signal in T1-WI, high signal in T2-WI fat suppressed, and enhances after gadolinium contrast, denoting also the inflammatory process. Additionally, similar signal changes are appreciated in the periosseous soft-tissues and a small juxtacortical abscess (see arrow) adjacent to the antero-medial tibial surface is visible. These findings are highly suggestive of chronic osteomyelitis complicated with a periosseous abscess.
Osteomyelitis is a multifaceted disease that comprehends three distinctive clinical and radiological entities: acute, subacute, and chronic osteomyelitis. This spectrum reflects among others: duration, patient’s age, site of infection, host susceptibility and inadequate therapy, the latter being important harbingers of subacute and chronic infection. The 6th week of evolution is the temporal frame used to define the chronic form.
Three routes of infection are possible: haematogenous, by contiguity, or direct implantation through a penetrating wound or an infected foreign body.
Osteomyelitis usually affects a single bone, being polyostotic in 7% of cases. Sites of predilection are the fast-growing and large metaphyses around the knee, wrist, and proximal humerus. Flat bones, vertebrae, and calcaneus are affected in 25% of cases.
The regional vascular anatomy around the physis differs according to age and elucidates the different haematogenous spread in infants, toddlers, and adults. Transphyseal blood supply during infancy originates the combined metaphyseal, epiphyseal, and joint involvement. Sites adjacent to apophyseal cartilage (metaphyseal equivalents) exhibit a similar vascular pattern and have therefore the same pattern of spread.
The clinical and laboratory signs are often elusive. It is often clinically silent and a causative organism is not identified in 25% of cases, particularly in the chronic form. Chronic osteomyelitis may be indolent for a long time and then reactivate, due to continuous low grade infection.
Imaging approach aims a timely and accurate diagnosis to prevent sequelae. All techniques should be considered and advantage taken of theirs specificities, in a tailored strategy for a given patient and a given institution.
Radiographs are usually the first step. The earliest sign is deep soft tissue swelling; bone destruction and periosteal reaction being visible 10-21 days after onset. Comparative views of the contralateral limb better appreciate subtle early findings.
Bone scintigraphy has moderate specificity and may help to localize osteomyelitis and distinguish it from cellulitis.
MR and CT provide complementary and detailed evaluation of osseous and soft tissue changes. Coronal or sagittal imaging is useful for biopsy and debridement planning, and for physis’ and epiphysis’ assessment. MRI is considered the gold standard for osteomyelitis evaluation (sensitivity: 88-100% and specificity: 75-100%). The penumbra sign is useful for subacute osteomyelitis detection, with a sensitivity of 75% and specificity of 90%. It is identified on unenhanced T1-WI as a thin and slightly hyperintense peripheral zone on Brodie’s abscess, probably due to granulation tissue.
Ultrasound application for soft tissues evaluation and abscess drainage guidance has encouraging reports. Ultrasound availability and low cost make it an attractive alternative for centres with limited access to cross-sectional imaging.
Acute osteomyelitis has often an aggressive appearance and can be mistaken for trauma, eosinophilic granuloma, leukemia or other aggressive neoplasms. The differential diagnosis of subacute and chronic osteomyelitis includes: chondroblastoma, eosinophilic granuloma, granulomatous infections, osteoid osteoma, or Ewing’s sarcoma.
Possible complications comprise septic arthritis, pathologic fracture, growth disturbances, and rarely squamous cell carcinoma decades after chronic osteomyelitis with longstanding sinus tract drainage. Early diagnosis and prolonged antibiotherapy are vital to eradicate osteomyelitis and prevent sequelae.
Chronic Osteomyelitis
Based on the provided anteroposterior X-ray of the knee and MRI images, the following main features can be observed:
Considering the patient’s prolonged left knee pain for two years, normal laboratory tests, and imaging findings of bone destruction, sequestrum, and a possible sinus tract, the following differential diagnoses should be considered:
Considering the patient’s age (11 years), duration of symptoms (two years of recurring knee pain), radiological findings of sequestrum (dead bone), bone destruction, a suspected sinus tract, and sclerotic margins, the comprehensive analysis suggests that chronic osteomyelitis is the most likely diagnosis. If feasible, a bone biopsy or aspiration could be performed to obtain definitive etiological evidence and confirm the final diagnosis.
1. Treatment Strategy Overview:
2. Rehabilitation and Exercise Prescription (FITT-VP Principle):
The rehabilitation goal is to maintain joint mobility, enhance muscle strength, and avoid functional loss due to prolonged immobilization. It should be conducted under the guidance of a specialist or rehabilitation therapist. The general steps can be as follows:
If severe pain, significant discomfort, or increasing local redness and swelling occur during the exercise, the patient should seek medical evaluation promptly. Given the child’s skeletal immaturity, care should be taken when considering jumping, running, or other high-impact activities; a thorough assessment is recommended to ensure safety.
This report is based solely on the provided clinical history and imaging data for reference purposes. It cannot replace an in-person consultation or professional medical opinion. Specific diagnostic and treatment decisions require correlation with clinical examination, laboratory results, and histopathological evidence, under the comprehensive assessment of a specialist.
Chronic Osteomyelitis