A 42-year-old male patient presented to the emergency department at 3:00 a.m. with malaise and right-sided intense chest pain that had occurred during the night. He denied experiencing trauma or recent surgical procedures. His medical history included diabetes mellitus, hypertension, mild chronic renal failure and Non-Hodgkin's lymphoma.
Physical examination revealed fever (38.0°C) with normal vital signs.
Laboratory studies showed leukocytosis, high CRP and serum creatinine of 1.8 mg/dL.
Chest CT performed at 4:17a.m. excluded the presence of pneumonia, but showed gas collection in the right pectoralis major muscle with thickening of its fascial planes and increased attenuation of the subcutaneous fat tissue suggesting oedema.
The patient was immediately treated with broad-spectrum antibiotics for a suspected soft-tissue infection but his clinical conditions worsened rapidly: chest pain increased, overlying skin became mottled, swollen and warm. The patient became tachycardic and dyspnoeic.
At 8:00a.m., he developed a severe shock condition requiring intubation and intensive cares.
At 8:32a.m. another CT examination showed the extension of the muscular involvement in the chest wall and the shoulder girdles with massive air collection due to the extensive gas gangrene, associated with intramuscular and subcutaneous fluid collection.
Shortly after the patient died in the ICU.
Necrotizing fasciitis (NF) is a rare, life-threatening infection of any layers within the soft tissue compartment (dermis, subcutaneous tissue, superficial fascia, deep fascia and muscle), that progresses rapidly through the fascial planes causing necrosis and destruction of the affected tissues. It is relatively uncommon, with a global prevalence reported to be about 4 cases per 1,000,000 population [1]. It affects all age groups, although it is more frequent in elderly patients, with a M/F ratio of 3:1 and a mortality estimated to be 21.5% [2, 3]. However, without treatment, the mortality reaches 100%. Most common localizations are lower extremities followed by the abdomen and the perineum (Fournier’s gangrene). Upper limbs and trunk are rarely involved.
Patients often have a history of trauma, including external injuries or surgical wounds. Common co-morbidities include diabetes mellitus, liver cirrhosis, chronic heart failure, renal failure, cancer, immunodeficiency and alcohol abuse [3].
The most common type of NF is a polymicrobial infection with both aerobic and anaerobic gas-forming bacteria (Clostridium, Proteus, Enterobacteriaceae) [3].
NF can be difficult to recognize in its early stages. The clinical presentation is often non-specific and causes delay in diagnosis: fever, malaise, tachycardia, tachypnoea, hypotension. Local symptoms and signs include: pain (typically disproportionate to the clinical findings), swelling and erythema of the overlying skin; in the advanced stages it evolves to skin ischaemia with bullae and blisters. In the fulminant form it presents with septic shock and multi-organ failure.
This challenging diagnosis may be facilitated by radiology. Plain radiography has low sensitivity and specificity, but is capable to show gas formation in soft tissues [4].
CT can play a vital role in suggesting the right diagnosis rapidly. The rapidity of CT compared with MRI may be advantageous for an emergent necrotizing fasciitis evaluation. The CT hallmarks are: thickening of nonenhancing fascial layers indicative of NF, air and fluid collection in soft tissues, muscular and fat stranding [5, 6]. CT also shows reactive lymphadenopathy, underlying infection sources and complications of tissue necrosis like vascular rupture [6, 7].
MRI is the modality of choice for detailed evaluation of soft-tissue infection with fluid collection and fascial thickening, but is often not performed for necrotizing fasciitis evaluation because its acquisition is time-consuming and will delay treatment [8].
Prompt diagnosis is mandatory to permit emergency surgical debridement, necrosectomy and fasciotomy of the affected tissues. Surgical intervention is life-saving and must be performed as early as possible. Patients should also be immediately treated with broad-spectrum antibiotics when NF is suspected.
Necrotizing fasciitis
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Based on the provided chest CT images, there is notable swelling of the right chest wall soft tissue. Gas density is observed within the subcutaneous fat and between muscle fascia (presenting as low density with foci of gas density), suggesting infectious gas accumulation. In some areas, the fascia appears significantly thickened with uneven enhancement and obvious fat stranding, indicating local edema or exudation.
No obvious signs of substantial parenchymal lesions are seen in the lung fields. The mediastinal structures are relatively midline, though some lymph node enlargement is noted locally. No clear bone destruction or fracture is observed. Overall imaging characteristics are consistent with a rapidly invasive infection of the soft tissue and fascial layers, producing gas.
Considering the patient’s sudden onset of severe chest pain during the night, previous comorbidities (diabetes, hypertension, chronic renal failure, lymphoma resulting in immunocompromised status), and the CT findings of chest wall fascial involvement with apparent gas formation, the most likely diagnosis is: Necrotizing Fasciitis (chest wall involvement).
Given the aggressive course of this disease and its high mortality rate, laboratory results (e.g., white blood cell count, C-reactive protein, lactate level) and possible microbiological testing should be performed promptly to confirm the diagnosis and initiate treatment as soon as possible. If the diagnosis remains in doubt, further MRI evaluation may be considered, or pathological evidence should be obtained during surgical exploration.
Principle: Because necrotizing fasciitis often requires extensive surgical debridement, the early stage focuses on wound healing and functional maintenance, the mid-stage on preventing muscle strength loss and joint range-of-motion limitations, and the late stage on rebuilding physical fitness and daily activity capacity. An individualized plan should be developed according to the patient’s overall condition, cardiopulmonary function, and the progression of surgical wound healing. The following is a brief phase-based example using the FITT-VP principle:
If the patient has limited cardiopulmonary function or other chronic diseases (e.g., renal insufficiency), exercise volume and approach should be further adjusted under guidance from cardiology or relevant specialists to ensure safety.
Disclaimer: This report is solely a reference analysis based on the provided information. It is not a substitute for in-person consultation or professional medical diagnosis and treatment. If you have any concerns, please consult a specialist promptly.
Necrotizing fasciitis