We report two cases of unusual focal bone enhancement secondary to brachiocephalic vein compression and paravertebral collateral circulation formation.
The first case had aortic valve replacement surgery complicated by post-operative mediastinitis with complex collections. Contrast enhanced CT scan showed numerous anterior chest wall and mediastinal collateral vessels with compression of the mid left brachiocephalic vein which reformed via collaterals more distally. New sclerotic-mimicking lesions in the lower cervical spine and upper thoracic vertebral bodies were seen. The lesions are not seen on non-contrast-enhancement CT (Fig. 1c), indicating vascular origin.
The second case had left upper lobe sleeve lobectomy for squamous cell carcinoma of the lung. Contrast-enhanced CT revealed a subpleural wedge-shaped area of scar tissue in the left upper lung zone, extending retrosternally and compressing the left brachiocephalic vein. Several dense foci were seen in the posterior part of the upper thoracic vertebral bodies relating to avidly enhancing surrounding collateral vessels. Again these were regarded perfusional in nature.
The main causes of superior vena cava (SVC) obstruction are malignancy and its associated treatment, iatrogenic causes such as venous catheterization and benign causes such as mediastinal fibrosis [1]. Mediastinitis is a rare but important complication of the median sternotomy, involving less than 1% of these patients, being associated with high mortality, morbidity and treatment cost [7]. Mediastinitis can sometimes lead to mediastinal fibrosis and its associated complications such as pulmonary hypertension or SVC obstruction as mentioned above [8].
The major collateral pathways involved in the SVC obstruction confirmed by superior venacavograms in literature are the hemiazygos-azygos, lateral thoracic, internal and external mammary and the vertebral plexus pathways [1, 2]. The vertebral plexus pathway uses the brachiocephalic, vertebral, intercostal, lumbar, and sacral veins to collateralize to the azygos and internal mammary venous pathways (Figure 3) [1, 9]. In such cases, the basivertebral veins become dilated within the basivertebral canal (Hahn's canal) and appear as bright areas in the posterior part of the vertebral body on contrast enhanced CT. On plain CT, the foramina of the basivertebral canal may increase in size as a clue of chronic venous dilatation (Fig. 1c).
Previous cases of vertebral venous plexus collaterals and basivertebral venous enhancement have been reported in patients with lung cancer treatment but none in patients with mediastinal fibrosis secondary to mediastinitis [3-6].
It is important to recognise these vertebral 'lesions' as intra-osseous venous enhancement and not as metastatic deposits, especially in patients with a previously known malignancy. The clue to this is prominence of paravertebral venous collaterals and a non-contrast study will help to confirm the vascular nature. Early recognition of this condition can avoid over-investigating these patients and exposing them to risk-potential invasive procedures such as biopsies.
Focal vertebral enhancement secondary to brachiocephalic vein stenosis and paravertebral collateral circulation formation.
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Based on the provided enhanced chest CT images, the following observations are noted:
Considering the clinical history (previous chest surgery/infection, possibly resulting in mediastinal fibrosis and compression of the brachiocephalic vein) and the imaging findings, the following diagnoses or differential diagnoses should be considered:
Based on the patient’s clinical history (past surgical mediastinal infection/fibrosis and prior chest surgery) and current imaging (compression of the brachiocephalic vein and notable enlargement of the basivertebral vein in the vertebral bodies), the most likely diagnosis is:
“Benign vascular changes (basivertebral vein enlargement) due to brachiocephalic vein compression caused by mediastinal fibrosis, resulting in collateral formation in the paravertebral venous plexus.”
For a 72-year-old patient, a gradual approach is recommended, focusing on safety and maintaining basic cardiopulmonary function:
Disclaimer: This report is based on limited available information and is provided for medical reference only. It should not substitute for in-person consultation or individualized advice from a qualified physician. If you have any questions or if your condition changes, please seek medical attention promptly.
Focal vertebral enhancement secondary to brachiocephalic vein stenosis and paravertebral collateral circulation formation.