A 44-year-old woman with no known medical illness complaining of right ankle medial malleolus swelling increasing in size for 6 months associated with intermittent pain upon movement. Physical examination showed soft mass at the medial aspect of the right ankle, unfixed to the skin, with tenderness.
The patient initially underwent right foot X-ray which showed no abnormalities. Subsequently soft tissue ultrasound was performed reporting a well-defined hypoechoic, vascular, oval-shaped mass measuring 2.3 x 1.5 cm located posteriorly to the medial malleolus in relation with the distal part of the posterior tibial nerve and the posterior tibial vessels (Fig. 1). Finally magnetic resonance imaging was performed to clarify the ultrasound findings.
MRI showed an oval-shaped well-defined soft tissue mass lesion at the posterior tibial neurovascular bundle which measured 2.5 x 1.7 x 1.5 cm in craniocaudal, transverse and anteroposterior dimensions. Exhibiting low T1-weighted signal intensity (Fig. 2, 3) and heterogeneous hyperintense T2-weighted (Fig. 4) and heterogeneous high proton density signal with post-contrast enhancement.
Background: Schwannoma is a tumour of the tissue that covers nerves known as the nerve sheath, it develops from schwann cells. They usually occur sporadically where the aetiology is unknown and its commonest location is the vestibular nerve, the facial or even the spinal nerve root. [1, 2]
We present a case with schwannoma feature in the posterior tibial nerve. Imaging is required for diagnosis. Ultrasound features of schwannoma include a hypoechoic vascular homogeneous eccentric oval or round mass with a diameter of 1-2 cm, furthermore, MRI features include a typical isointense mass at T1-weighted and enhancement at T1-weighted with contrast, heterogeneously hyperintense in T2-weighted images.
It demonstrates different signs such as the split fat sign represented as fat deposition around the lesion found on the T1-weighted image. The target sign high T2-weighted peripheral signal and the fascicular sign showing multiple ring-like structures within the mass. These features were found in our case even though the location was not suggestive of a schwannoma. [3]
A histological examination of the mass demonstrated an encapsulated lesion moderately cellular and showed A and B zonation with nuclear spindle cells in a palisading pattern, these are the typical architectural patterns of schwannoma.
According to the WHO classification, schwannoma is classified as cellular schwannomas which are made of mainly Antoni A tissue (highly ordered) with no verocay bodies. Second classification include melanotic schwannoma containing pigmented melanin and finally the plexiform schwannoma found at the skin or the subcutaneous tissue. [4-7]
Outcomes: The radiological findings included a smooth surface with regular border, small-sized, which are features of a benign lesion. The histopathology confirmed it to be a benign type of schwannoma as imaging criteria are not highly reliable for differentiating whether a mass is benign or malignant. The patient underwent mass excision as per the patient’s preference, physiotherapy for rehabilitation and was given neurotin synthesizing GABA neurotransmitter to bind onto the receptors and reduce pain.
Schwannoma has a good prognosis with low recurrence rate. [8]
Take home message: Schwannoma of the posterior tibial nerve is a condition which is why an awareness must be made on the diagnosis of such a condition as its location could be misleading. Physicians should make good use of the radiological features of schwannoma on MRI to eliminate other differential diagnoses. In addition, a multi-disciplinary approach is required to reach a final diagnosis.
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Schwannoma of the peripheral nerve sheath
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A soft tissue mass is visible in the medial malleolus area of the patient’s right ankle. Ultrasound shows relatively well-defined margins, uniformly low echo, and visible blood flow signals, presenting an elliptical or round shape with a rich local blood supply.
MRI (T1-weighted images) reveals that the lesion appears isointense or slightly hypointense with relatively clear margins. After contrast injection, enhancement of the lesion is observed. On T2-weighted images, the center of the mass exhibits relatively low signal, whereas the periphery shows higher signal, forming a “target sign.” The surrounding fat layer presents a “split-fat sign.” In transverse sections, the lesion may display a “fascicular sign,” indicative of a nerve sheath-related lesion.
Considering the patient’s imaging features and medical history, a neurogenic tumor is highly suspected. Among these, a schwannoma (Schwannoma) is the most likely diagnosis.
Based on postoperative pathology and imaging findings, in conjunction with the patient’s clinical symptoms and physical examination, the most likely final diagnosis is Schwannoma. This tumor is typically benign, arising from Schwann cells, and commonly affects large- or medium-sized nerves in the limbs.
If there are indications suggesting malignancy or atypical pathological findings, further surgical resection and pathological examination may be necessary to confirm the lesion’s nature.
1. Treatment Strategy:
For benign schwannomas, treatment can be decided based on clinical symptom severity and patient preference, ranging from surgical resection to conservative observation:
2. Rehabilitation and Exercise Prescription:
Post-surgery or during conservative treatment, the rehabilitation plan should be guided by the patient’s joint mobility, muscle strength, and pain level. Emphasis is placed on protecting the surgical site or pain area while progressively enhancing ankle function and strengthening surrounding muscles. Key steps include:
Proper and moderate rehabilitation can help restore ankle function, reduce pain, and prevent secondary injury. If significant swelling, severe pain, or worsening neurological symptoms occur during exercise, seek medical evaluation promptly.
Disclaimer: This analysis report provides a reference opinion based on existing patient history and imaging data. It is not a substitute for in-person consultation or professional medical advice. Should any concerns arise or the condition change, please seek immediate medical attention.
Schwannoma of the peripheral nerve sheath