A case of schwannoma at the posterior tibial nerve

Clinical Cases 17.04.2020
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Section: Musculoskeletal system
Case Type: Clinical Cases
Patient: 44 years, female
Authors: Heba Al Saad, Osama Sharaf
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AI Report

Clinical History

A 44-year-old woman with no known medical illness complaining of right ankle medial malleolus swelling increasing in size for 6 months associated with intermittent pain upon movement. Physical examination showed soft mass at the medial aspect of the right ankle, unfixed to the skin, with tenderness.

Imaging Findings

The patient initially underwent right foot X-ray which showed no abnormalities. Subsequently soft tissue ultrasound was performed reporting a well-defined hypoechoic, vascular, oval-shaped mass measuring 2.3 x 1.5 cm located posteriorly to the medial malleolus in relation with the distal part of the posterior tibial nerve and the posterior tibial vessels (Fig. 1). Finally magnetic resonance imaging was performed to clarify the ultrasound findings.

MRI showed an oval-shaped well-defined soft tissue mass lesion at the posterior tibial neurovascular bundle which measured 2.5 x 1.7 x 1.5 cm in craniocaudal, transverse and anteroposterior dimensions. Exhibiting low T1-weighted signal intensity (Fig. 2, 3) and heterogeneous hyperintense T2-weighted (Fig. 4) and heterogeneous high proton density signal with post-contrast enhancement.

Discussion

Background: Schwannoma is a tumour of the tissue that covers nerves known as the nerve sheath, it develops from schwann cells. They usually occur sporadically where the aetiology is unknown and its commonest location is the vestibular nerve, the facial or even the spinal nerve root. [1, 2]

We present a case with schwannoma feature in the posterior tibial nerve. Imaging is required for diagnosis. Ultrasound features of schwannoma include a hypoechoic vascular homogeneous eccentric oval or round mass with a diameter of 1-2 cm, furthermore, MRI features include a typical isointense mass at T1-weighted and enhancement at T1-weighted with contrast, heterogeneously hyperintense in T2-weighted images.

It demonstrates different signs such as the split fat sign represented as fat deposition around the lesion found on the T1-weighted image. The target sign high T2-weighted peripheral signal and the fascicular sign showing multiple ring-like structures within the mass. These features were found in our case even though the location was not suggestive of a schwannoma. [3]

A histological examination of the mass demonstrated an encapsulated lesion moderately cellular and showed A and B zonation with nuclear spindle cells in a palisading pattern, these are the typical architectural patterns of schwannoma.

According to the WHO classification, schwannoma is classified as cellular schwannomas which are made of mainly Antoni A tissue (highly ordered) with no verocay bodies. Second classification include melanotic schwannoma containing pigmented melanin and finally the plexiform schwannoma found at the skin or the subcutaneous tissue. [4-7]

Outcomes: The radiological findings included a smooth surface with regular border, small-sized, which are features of a benign lesion. The histopathology confirmed it to be a benign type of schwannoma as imaging criteria are not highly reliable for differentiating whether a mass is benign or malignant. The patient underwent mass excision as per the patient’s preference, physiotherapy for rehabilitation and was given neurotin synthesizing GABA neurotransmitter to bind onto the receptors and reduce pain.

Schwannoma has a good prognosis with low recurrence rate. [8]

Take home message: Schwannoma of the posterior tibial nerve is a condition which is why an awareness must be made on the diagnosis of such a condition as its location could be misleading. Physicians should make good use of the radiological features of schwannoma on MRI to eliminate other differential diagnoses. In addition, a multi-disciplinary approach is required to reach a final diagnosis.

Written informed patient consent has been obtained.

Differential Diagnosis List

Schwannoma of the peripheral nerve sheath
Neurofibroma
Giant cell tumour of tendon sheath

Final Diagnosis

Schwannoma of the peripheral nerve sheath

Figures

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Ultrasonography image showing mass posterior to the medial malleolus of the right ankle.

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MRI showing T1-weighted sagittal view on fast spin echo (fSE) cuts showing iso to hypointense mass with split fat sign of the

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MRI axial view T1-weighted fast spin (FS) with contrast showing target and fascicular sign of schwannoma mass

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MRI axial T2 –weighted fast spin (FS) heterogeneously hyperintense regular bordered mass at the posterior tibia.