Skin rash and muscle weakness
Skin rash Scaly lesions on dorsum of hands Muscle weakness - especially affecting proximal muscle groups Generalised muscle ache - tender on examination On long-term, intermittent steroid therapy
This is an inflammatory polymyopathy of striated muscle accompanied by dermatological features. Characteristic soft tissue abnormalities are oedema followed by atrophy. In the healing phase there may be extensive soft tissue calcification in subcutaneous and intermuscular planes resulting in severe flexion contractures in the later stages. Osteopaenia may be a prominent feature of the condition compounded by the effect of steroid therapy, and the latter may be complicated by avascular necrosis. Secondary infection may also complicate steroid therapy as a result of immune-suppression. Opportunistic lung infections may be one such manifestation. Diffuse, multiple or generalised soft tissue calcification may be seen in:- hyperparathyroidism and renal osteodystrophy other disorders of calcium and phosphate metabolism eg. hypoparathyroidism, chronic haemodialysis, milk-alkali syndrome, etc. scleroderma dermatomyositis polyarteritis nodosa Raynaud’s syndrome rheumatoid arthritis systemic lupus erythematosus sarcoidosis gout ochronosis Ehler’s-Danlos syndrome Werner’s syndrome (adult progeria)
DERMATOMYOSITIS. Steroid-induced avascular necrosis.
1. The anteroposterior (AP) X-ray of the pelvis shows bilateral artificial hip joint prostheses with reduced bone density, indicating a certain degree of bone loss.
2. Irregular calcifications are visible in the soft tissues around both hips and the proximal thighs, distributed subcutaneously and within muscle compartments; some regions demonstrate extensive band-like or clustered deposits.
3. The chest X-ray (PA view) suggests generally normal pulmonary translucency without obvious localized consolidation or cavitation. However, vigilance is advised for potential opportunistic infections or small focal lesions under immunosuppressed conditions.
Based on the patient’s clinical manifestations (skin rash, muscle weakness), along with imaging findings of soft tissue calcification and bone loss, the following diagnoses or differential diagnoses should be considered:
Combining the patient’s age (37 years), typical skin rash, muscle weakness, and previous clinical history (inflammatory myopathy), with imaging findings of subcutaneous and intramuscular calcifications and decreased bone density, the most consistent diagnosis is
Dermatomyositis.
Further confirmation may require additional tests such as muscle enzymes (CK, LDH), electromyography, and muscle biopsy. Screening for potential complications—e.g., opportunistic lung infections or osteonecrosis—should also be considered.
The primary treatment for dermatomyositis involves glucocorticoids and immunosuppressive therapy, potentially combined with intravenous immunoglobulins. Surgical intervention could be considered in cases of severe joint or soft tissue involvement.
During the course of treatment, regular monitoring of muscle enzymes and lung function is essential, and vigilance for osteoporosis, aseptic necrosis, and opportunistic infections is recommended.
During acute flare-ups or when the condition is unstable, it is advisable to reduce exercise intensity and duration. Once muscle inflammation stabilizes, exercise volume should be gradually increased to avoid exacerbation or new injuries.
Disclaimer: This report is a reference-based medical analysis and does not substitute for an in-person consultation or the advice of a qualified physician. Please consult a specialist for an accurate diagnosis and treatment plan.
DERMATOMYOSITIS. Steroid-induced avascular necrosis.