Synovial Cyst of Popliteal Artery

Clinical Cases 12.02.2002
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Section: Musculoskeletal system
Case Type: Clinical Cases
Patient: 44 years, male
Authors: F. Vanhoenacker, W. Lybaert, J. De Leersnijder, L. De Beuckeleer, A.M. De Schepper
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AI Report

Clinical History

The clinical presentation and imaging findings were diagnostic for cystic adventitial disease of the popliteal artery.

Imaging Findings

A patient presented with a two-month history of intermittent claudication of the right leg.
Duplex-sonography (US) of the right knee before (not shown) and after exercise shows a hypoechoic lesion with some internal septations, compressing the lumen of the popliteal artery. The cystic lesion increases in size after exercise and after onset of ischemic pain sensation in the lower limb.
Contrast-enhanced CT scan of the right knee demonstrates a non enhancing cystic lesion, encasing the popliteal artery (arrows).
MRI of the right knee shows on the mid-sagittal TSE T2-weighted image a hyperintense crescent lesion within the wall of the popliteal artery (arrows). Sagittal TSE T2-weighted image through the lateral knee compartment visualizes a small hyperintense stalk pointing towards the lateral knee compartment (arrow).
The clinical presentation and imaging findings were diagnostic for cystic adventitial disease of the popliteal artery. The cystic nature, as well as the communication with the knee joint, paralleling a capsular branch of the popliteal artery, was confirmed upon surgical exploration and treatment. Histological examination of the cyst wall and content revealed a true synovial cyst.

Discussion

Cystic adventitial disease of the popliteal artery is a rare cause of intermittent claudication especially affecting middle-aged men. Preferential location is the popliteal artery, but other arteries and even veins may be affected, around a joint.
Histopathologically, the cyst wall may be lined by true synovial cells or by a (dis)continuous layer of pseudosynovial cells (ganglion cyst).
A communication with the adjacent joint (along the course of a capsular branch of the adjacent artery) is possible, and has been demonstrated in multiple cases by imaging and/or surgery.
The pathogenesis is still debated and hypothetical. It include the embryological hypothesis, in which pluripotent mesenchymal cells destined to form the knee, hip, wrist or ankle joints are incorporated into the nearby and adjacent nonaxial vessels in the 15-22nd week of gestation. Later in life, these synovial-like cell rests are responsible for the formation of an adventitial cyst, when mucoid material is secreted. The synovial theory, in which the cyst is formed by a herniation of synovium through a breach in the adjacent circulation, seems more logical to understand. The possible communication with the adjacent joint, the fluctuating volume, and the similar histological composition supports this theory.
Essential imaging techniques are color duplex US and T2-weighted MR imaging. US may confirm the cystic nature and the location of the cyst in the arterial wall, as well as the changing size of the cyst after exercise. Color Doppler US affords to evaluate the degree of the vessel stenosis. MRI (especially the T2-weighted images) is an excellent tool for the precise localization of the cyst and to demonstrate the possible communication with the adjacent joint. This is important since resection of this joint communication is essential to avoid postsurgical recurrence.

Differential Diagnosis List

Cystic adventitial disease

Final Diagnosis

Cystic adventitial disease

Liscense

Figures

Duplex-sonography (US) of the right knee

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Duplex-sonography (US) of the right knee

Contrast-enhanced CT scan of the right knee

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Contrast-enhanced CT scan of the right knee

MRI of the right knee

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MRI of the right knee
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MRI of the right knee