The clinical presentation and imaging findings were diagnostic for cystic adventitial disease of the popliteal artery.
A patient presented with a two-month history of intermittent claudication of the right leg.
Duplex-sonography (US) of the right knee before (not shown) and after exercise shows a hypoechoic lesion with some internal septations, compressing the lumen of the popliteal artery. The cystic lesion increases in size after exercise and after onset of ischemic pain sensation in the lower limb.
Contrast-enhanced CT scan of the right knee demonstrates a non enhancing cystic lesion, encasing the popliteal artery (arrows).
MRI of the right knee shows on the mid-sagittal TSE T2-weighted image a hyperintense crescent lesion within the wall of the popliteal artery (arrows).
Sagittal TSE T2-weighted image through the lateral knee compartment visualizes a small hyperintense stalk pointing towards the lateral knee compartment (arrow).
The clinical presentation and imaging findings were diagnostic for cystic adventitial disease of the popliteal artery. The cystic nature, as well as the communication with the knee joint, paralleling a capsular branch of the popliteal artery, was confirmed upon surgical exploration and treatment. Histological examination of the cyst wall and content revealed a true synovial cyst.
Cystic adventitial disease of the popliteal artery is a rare cause of intermittent claudication especially affecting middle-aged men. Preferential location is the popliteal artery, but other arteries and even veins may be affected, around a joint.
Histopathologically, the cyst wall may be lined by true synovial cells or by a (dis)continuous layer of pseudosynovial cells (ganglion cyst).
A communication with the adjacent joint (along the course of a capsular branch of the adjacent artery) is possible, and has been demonstrated in multiple cases by imaging and/or surgery.
The pathogenesis is still debated and hypothetical. It include the embryological hypothesis, in which pluripotent mesenchymal cells destined to form the knee, hip, wrist or ankle joints are incorporated into the nearby and adjacent nonaxial vessels in the 15-22nd week of gestation. Later in life, these synovial-like cell rests are responsible for the formation of an adventitial cyst, when mucoid material is secreted. The synovial theory, in which the cyst is formed by a herniation of synovium through a breach in the adjacent circulation, seems more logical to understand. The possible communication with the adjacent joint, the fluctuating volume, and the similar histological composition supports this theory.
Essential imaging techniques are color duplex US and T2-weighted MR imaging. US may confirm the cystic nature and the location of the cyst in the arterial wall, as well as the changing size of the cyst after exercise. Color Doppler US affords to evaluate the degree of the vessel stenosis. MRI (especially the T2-weighted images) is an excellent tool for the precise localization of the cyst and to demonstrate the possible communication with the adjacent joint. This is important since resection of this joint communication is essential to avoid postsurgical recurrence.
Cystic adventitial disease
Based on the provided ultrasound, CT, and MRI images, a cystic lesion can be observed either within the arterial wall or adjacent to it in the popliteal region behind the knee. Ultrasound examination shows a low-echoic or anechoic cystic structure in the outer arterial layer, with fluid signals inside; its size may vary depending on posture or activity. Color Doppler can reveal narrowing of the arterial lumen and help evaluate hemodynamic changes. On MRI (especially T2-weighted images), there is a focal or linear high-signal area within or near the popliteal arterial wall in a cystic shape, and in some cases, there may be signs of connection with the adjacent joint capsule. Overall, the imaging features are typical of a cystic adventitial disease.
Considering the clinical presentation (intermittent claudication, male patient, lesion location) and the radiographic findings, cystic adventitial disease of the popliteal artery is the most likely diagnosis.
Integrating the patient’s age, symptoms (intermittent claudication), imaging findings (cystic lesion in or around the arterial adventitia, possibly connecting to the joint), and the typical demographic and anatomical distributions of this condition, cystic adventitial disease of the popliteal artery is the most probable diagnosis.
1. Treatment Strategy:
The primary treatment for this condition is surgical intervention, including excision of the cyst and closure of any potential connection to the joint capsule. If the cyst is large and causes significant arterial narrowing or occlusion, surgical indications are stronger. In early or mild cases, physical therapy and pain management may be considered while monitoring for progression.
If there is a high risk of vascular stenosis, an assessment for vascular reconstruction or stent placement might be needed. However, for cystic adventitial disease of the popliteal artery, priority is usually given to removing the lesion and blocking any joint capsule communication to reduce recurrence.
2. Rehabilitation and Exercise Prescription (FITT-VP Principle):
Disclaimer: This report is for medical reference only and cannot replace the in-person consultation and diagnosis of a qualified physician. Specific treatment plans should be determined by a specialist based on the individual patient’s condition.
Cystic adventitial disease