Pseudogout (calcium pyrophosphate dihydrate crystal deposition disease)

Clinical Cases 21.03.2002
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Section: Musculoskeletal system
Case Type: Clinical Cases
Patient: 41 years, male
Authors: H J Williams
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Details
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AI Report

Clinical History

The patient attended accident and emergency with a 4-day history of right knee pain and swelling.

Imaging Findings

The patient attended accident and emergency with a 4-day history of right knee pain and swelling. There was no history of trauma, no other joints were affected and he was previously fit and well. On examination there was a knee joint effusion with pain and tenderness. Inflammatory markers and white cell count were mildly elevated (ESR 40, WCC 13 x 109/l, neutrophils 10.6 x 109/l), but culture and gram stain of aspirated joint fluid revealed no evidence of infection. Radiographs of the right knee showed a joint effusion and calcification of both menisci (chondrocalcinosis), (fig. 1a, b, c). There was also minimal loss of joint space in the medial compartment of the joint. A clinical diagnosis of pseudogout (calcium pyrophosphate dihydrate crystal deposition disease) was made.

Discussion

Pseudogout is an arthropathy associated with calcium pyrophosphate dihydrate crystal deposition. It is predominantly a disease of the elderly and commonly presents with an acute 'self-limiting' synovitis. The classic triad is that of pain, cartilage calcification and joint destruction. The patient may have any combination of one or more of this triad at any time. The disease can also present with a chronic arthritis or as an incidental finding, and familial and metabolic disease-associated forms can occur. Acute pseudogout may be triggered by direct trauma to the joint, intercurrent illness, surgery, or blood transfusion. Aspirated joint fluid is often turbid or bloodstained with raised cell count (usually >90% neutrophils) and the diagnosis is confirmed by the finding of calcium pyrophosphate dihydrate crystals in the fluid. During an attack of pseudogout there is often a moderate acute phase response with elevation of plasma viscosity, ESR, acute phase reactants (e.g. c-reactive protein) and peripheral white cell count (predominantly neutrophils).

Cartilage calcification (chondrocalcinosis) can occur in any joint, but tends to affect predominantly the medial and lateral compartments of the knee, the triangular fibrocartilage of the wrist and the symphysis pubis. Chondrocalcinosis at these sites is virtually diagnostic of pseudogout. The associated joint destruction is indistinguishable from degenerative joint disease. The joints most commonly affected by the associated degenerative disease are the shoulder, elbow, radiocarpal and patellofemoral joints. Occasionally the arthropathy of pseudogout causes such severe joint destruction that it mimics a neuropathic or Charcot joint.

Differential Diagnosis List

Pseudogout (calcium pyrophosphate dihydrate crystal deposition disease)

Final Diagnosis

Pseudogout (calcium pyrophosphate dihydrate crystal deposition disease)

Liscense

Figures

Anteroposterior (AP) and lateral views of the right knee

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Anteroposterior (AP) and lateral views of the right knee
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Anteroposterior (AP) and lateral views of the right knee
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Anteroposterior (AP) and lateral views of the right knee