The patient attended accident and emergency with a 4-day history of right knee pain and swelling.
The patient attended accident and emergency with a 4-day history of right knee pain and swelling. There was no history of trauma, no other joints were affected and he was previously fit and well. On examination there was a knee joint effusion with pain and tenderness. Inflammatory markers and white cell count were mildly elevated (ESR 40, WCC 13 x 109/l, neutrophils 10.6 x 109/l), but culture and gram stain of aspirated joint fluid revealed no evidence of infection. Radiographs of the right knee showed a joint effusion and calcification of both menisci (chondrocalcinosis), (fig. 1a, b, c). There was also minimal loss of joint space in the medial compartment of the joint. A clinical diagnosis of pseudogout (calcium pyrophosphate dihydrate crystal deposition disease) was made.
Pseudogout is an arthropathy associated with calcium pyrophosphate dihydrate crystal deposition. It is predominantly a disease of the elderly and commonly presents with an acute 'self-limiting' synovitis. The classic triad is that of pain, cartilage calcification and joint destruction. The patient may have any combination of one or more of this triad at any time. The disease can also present with a chronic arthritis or as an incidental finding, and familial and metabolic disease-associated forms can occur. Acute pseudogout may be triggered by direct trauma to the joint, intercurrent illness, surgery, or blood transfusion. Aspirated joint fluid is often turbid or bloodstained with raised cell count (usually >90% neutrophils) and the diagnosis is confirmed by the finding of calcium pyrophosphate dihydrate crystals in the fluid. During an attack of pseudogout there is often a moderate acute phase response with elevation of plasma viscosity, ESR, acute phase reactants (e.g. c-reactive protein) and peripheral white cell count (predominantly neutrophils).
Cartilage calcification (chondrocalcinosis) can occur in any joint, but tends to affect predominantly the medial and lateral compartments of the knee, the triangular fibrocartilage of the wrist and the symphysis pubis. Chondrocalcinosis at these sites is virtually diagnostic of pseudogout. The associated joint destruction is indistinguishable from degenerative joint disease. The joints most commonly affected by the associated degenerative disease are the shoulder, elbow, radiocarpal and patellofemoral joints. Occasionally the arthropathy of pseudogout causes such severe joint destruction that it mimics a neuropathic or Charcot joint.
Pseudogout (calcium pyrophosphate dihydrate crystal deposition disease)
Based on the provided anteroposterior and lateral X-ray images of the right knee joint, the following main features are observed:
Based on the patient’s clinical presentation (acute joint pain, swelling) and radiological findings (cartilage or subchondral calcifications), the following diagnoses and differentials should be considered:
Combining the evident cartilage calcifications on the X-ray, acute right knee pain, swelling, and common triggers of acute pseudogout (such as trauma, surgery, or physiological stress), the most likely diagnosis is:
Pseudogout (CPPD arthritis).
Further confirmation can be achieved if calcium pyrophosphate crystals are found in joint aspirate. Additional examinations, such as joint fluid culture and blood tests (e.g., white blood cell count, C-reactive protein), may be necessary to rule out infection or other causes.
Treatment Strategies:
Rehabilitation and Exercise Prescription (FITT-VP Principle):
Safety Considerations:
Throughout rehabilitation, monitor any changes in joint pain or swelling. If significant redness, swelling, or functional limitation worsens, or if complications are suspected, seek medical evaluation promptly.
Disclaimer: The above report is a reference analysis based on existing data and cannot replace an in-person consultation or the opinion of a qualified physician. Actual diagnosis and treatment should be determined by professional medical staff, incorporating the patient’s specific condition and further test results.
Pseudogout (calcium pyrophosphate dihydrate crystal deposition disease)