The patient presented with swelling and chronic pain of the forearm without any medical history.
The patient presented with swelling and chronic pain of the forearm. A radiogram demonstrated cortical lesions characteristic of melorheostosis. No pathologic prooff has been obtained, the diagnosis was based on typical plain film findings.
Melorheostosis is a rare bone disease. The cause and pathogenesis are not known. The disease does not appear to be hereditary. It manifests after early childhood; occasionally, however, the initial signs appear in adult patients. Initial clinical manifestations include swelling and pain of joints and limitation of motion, muscle contracture, and tendon and ligament contracture.
Radiological manifestations are commonly limited to a single limb in which one or more bones may be affected. The abnormalities are rarely seen in the skull and facial bones, vertebrae or ribs.
This disorder presents as an irregular thickening of the cortex along one side of a bone or the bones of one extremity. The thickening may be external, internal or both. The appearance has been likened to molten wax flowing down the side of a candle. This sclerotic bone appearance may involve one side of the tubular bones of the upper or lower extremity affecting the carpus and tarsus as well as the metacarpals, metatarsals or phalanxes. Soft tissue calcifications and ossifications are not infrequent and may lead to ankylosis of the joint.
If the disease begins early in life the epiphyses may fuse prematurely causing shortening of the involved extremity. The lesions usually cease progressing when skeletal growth is complete. Regression has not been noted. Growth disturbance can be severe leading to joint contracture, foot deformity or scoliosis. The disease can result in considerable deformity and disability.
Scintigraphy may reveal areas of increased uptake of radionuclide. With MR imaging, bone and soft tissue lesions are of low signal intensity on both T1 and T2 sequences.
The disease can accompany tuberous sclerosis, Gardner's syndrome, fibrous dysplasia and infantile cortical hyperostosis.
During the course of melorheostosis, life expectancy does not seem to be shortened.
The main differential diagnosis of hyperostotic lesions include osteoma, osteopoikilosis and osteopathia striata; however, the location of the disease and the cortical thickening are specific to melorheostosis. The cortical changes must be distinguished from periostistis that occurs as a response to an adjacent osseous process (such as neoplasm, infection or trauma) and from hyperostosis that accompanies congenital disorders.
Melorheostosis
Based on the provided forearm X-ray, the following findings are observed:
Overall radiological characteristics suggest a localized sclerotic bone change, accompanied by unilateral enlarged cortical overgrowth. In conjunction with clinical presentations, rare bone diseases should be considered.
Considering the patient is a 21-year-old male with prolonged forearm swelling and chronic pain, and radiographic findings of unilateral cortical thickening, the following conditions should be taken into account:
From both the radiological features and the clinical correlation, the “dripping wax” cortical thickening is most indicative of Melorheostosis. In instances of significant unilateral cortical thickening, this diagnosis should be prioritized.
Based on:
A comprehensive judgment suggests that the most likely diagnosis is: Melorheostosis (Unilateral Bone Sclerosis).
If further confirmation is needed, CT 3D reconstruction or MRI (to identify soft tissue changes) can be performed, and a bone biopsy may be considered to exclude other rare bone disorders.
In planning rehabilitation, it is essential to ensure the safety of bones and joints while gradually restoring and maintaining normal function. The FITT-VP principle may serve as a guideline:
Example training routine (adjust as needed for individual conditions):
This report is based on available data and general medical knowledge, provided for reference only. It does not replace in-person consultation or professional medical advice. In case of any doubts or worsening symptoms, please seek prompt evaluation by a specialist and consider further examinations for accurate diagnosis and treatment.
Melorheostosis