Soft tissue mass in the palm of the hand and carpal tunnel syndrome
A mechanic had a mass in the left palm that had been enlarging for several months. Decreased grip strength, numbness and tingling in the fingers had developed after minor trauma. The patient had no other clinical symptoms or history. We performed x rays, sonography and MRI with a GE Profile 0.2T. X rays showed a soft tissue mass in the palm. Sonography showed that the mass was in the middle of the carpal tunnel and had a cablelike appearance. MR images showed longitudinally orientated cylindrical areas of low signal intensity surrounded by adipose tissue in a diffusely thickened median nerve.
Fibrolipomatous Hamartoma also known as lipomatosis of the median nerve is a rare benign lesion. More than 80% of these tumors are exclusively seen in the median nerve (1). It occurs most often at birth or infants and less commonly in children and young adults. There is no known cause or hereditary predisposition for this lesion, although hypertrophy of mature fat and fibroblasts in the epineurium has been postulated. The clinical manifestation is a slowly growing mass at the wrist, hand or forearm. Pain and neurological symptoms including carpal tunnel syndrome may be associated lately with lipomatosis of the median nerve. Macrodatyly is seen in 27% - 67% and has been referred to as macrodystrophia lipomatosa( 2, 3, 4). The MR appearance is unique and characteristic. The longitudinally orientated cylindrical region of signal void seen on all sequences represents the nerve fascicles and accompanying epineural and perineural fibrosis. These structures are separated by areas with signal intensity of fat, which represent the infiltrating mature fat cells in the interfascicular connective tissue (5). The differential diagnosis includes intraneural lipoma, ganglion cyst, traumatic neuroma and vascular malformations. Treatment includes carpal tunnel release. Surgical excision is controversial, motor and sensitive deficits have been reported (6,7).
Fibrolipomatous Hamartoma of the Median Nerve
The patient is a 30-year-old male, presenting with a soft tissue mass in the palmar region accompanied by symptoms of carpal tunnel syndrome. Based on the provided X-ray and MRI images, the following observations are noted:
Based on the patient's age, symptoms, and imaging changes, potential diagnoses or differential diagnoses include:
Based on these imaging characteristics (i.e., “cable-like” fatty infiltration of the median nerve), as well as the patient’s chronic slow-growing soft tissue mass and signs of carpal tunnel syndrome, the most likely diagnosis is Fibrolipomatous Hamartoma of the Median Nerve.
Further confirmation may require histopathological examination, but the combination of clinical and imaging data usually allows for a relatively accurate diagnosis.
For confirmed fibrolipomatous hamartoma, the main treatment goal is to relieve local pressure and improve function. Possible strategies include:
Regarding rehabilitation and exercise prescriptions, a gradual and individualized approach is recommended (following the FITT-VP principle: frequency, intensity, time, type, volume progression, and personalization).
This report is a reference analysis based on current clinical and imaging information and does not replace in-person diagnosis by a professional medical institution. If you have any concerns or if symptoms worsen, please seek medical attention promptly for further evaluation and treatment.
Fibrolipomatous Hamartoma of the Median Nerve